The role of epigenetics in cancer heterogeneity

Epigenetics in the context of cancer is still poorly explored. In the last two decades it has become apparent that cancer cells within a tumour may have distinctive genetic and epigenetic features which can be affected by anticancer treatments negatively or positively. This article summarises present knowledge on the role of the epigenome in tumourigenesis and subsequent growth, as well as discussing the links between genetics and epigenetics in cancer.

The potential partial overlap of genetic influences on schizophrenia and bipolar disorder, as demonstrated by quantitative and genetic molecular studies.

Do genetic variants increase the susceptibility of humans to psychological disorders such as schizophrenia, bipolar disorder, and schizoaffective disorder? How may they be comparable with respect to their genetic origins?

Electron Microscope Simulator

Electron microscopy (EM) is a fundamental technique which can be used to investigate the ultrastructure of cells, microstructure of inorganic crystals, and the structures of proteins. It has become an essential investigative approach in almost all scientific disciplines, yet it is hard for the curious student to get easy access to such a facility that would complement their scientific education. In this article, this issue is addressed and a feasible solution described by bringing to life an online simulator that can be an essential tool in the students’ learning. This simulator aims to mimic a real scanning electron microscope (SEM), walking the user through a tutorial that explains every essential function of the instrument.

The Tale of Naegleria fowleri and Primary Amoebic Meningoencephalitis

Primary amoebic meningoencephalitis (PAM) is a destructive brain disease caused by the thermophilic free-living amoeba, Naegleria fowleri. One could get infected by this amoeba when exposed to warm, fresh water, typically from rivers and lakes. The amoeba enters the host through the nasal cavity during recreational water activities. PAM has an incredibly high mortality rate due to its being hard to diagnose, its fast progression, and rarity. Targeted diagnostic tests can identify the disease and treatment is available, but a prompt diagnosis and treatment are required to successfully cure the disease.

The abundance of the nitroaromatics 2-methyl-5-nitroaniline, 1,3-dinitrobenzene, and 2,6-dinitrotoluene in the body of water in close proximity to the industrial site of Grangemouth.

Nitroaromatics are a common waste product found at the industrial sites, frequently used in various manufacturing processes. They can infiltrate into the bodies of water and contaminate them, posing a threat not only to the environment but also to human health. The specific nitroaromatics investigated in this research are 2-methyl-5-nitroaniline, 1,3-dinitrobenzene, and 2,6-dinitrotoluene and their abundance in the River Carron in relation to their distance to the industrial site of Grangemouth.